I noticed while trying to sign into my American Express account that clicking in the username did not make the drop down with 1Passowrd. If I hit command-bakcword slash it did not bring up 1PW and if I click on the Safari extension it comes up with Amex the first option however hitting autofill does not enter username and PW but instead opens the search bar of the safari window.
1Password Version: 80500057,
Extension Version: 2.1.4
OS Version: 12.2 Beta (21D5025f)