After some time, the 1Password extension gets stuck locked. I'm not sure exactly what triggers it, only that it seems to happen after the browser has been running for a while (hours). Restarting the browser, or even just toggling desktop integration, fixes the issue until it happens again. 1Password Mini works fine (but doesn't seem to recognize the browser). Here's a video of what the issue looks like when it happens. Hope this helps!
Edge v90.0.818.56 (extension installed via the Chrome web store)
1Password Version: 7.8.2.BETA-0
Extension Version: 1.25.6 beta
OS Version: macOS 11.3
Sync Type: 1Password Account